Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study
Identifieur interne : 000D98 ( Main/Exploration ); précédent : 000D97; suivant : 000D99Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study
Auteurs : Anwar E. AhmedSource :
- Epidemiology and Infection [ 0950-2688 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Démographie, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Mâle, Nourrisson, Santé mondiale, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie.
- MESH :
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- mortalité : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Adolescent, Adulte, Adulte d'âge moyen, Démographie, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Mâle, Nourrisson, Santé mondiale, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Coronavirus Infections (mortality), Coronavirus Infections (virology), Demography, Female, Global Health, Humans, Infant, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Risk Factors, Survival Rate.
- MESH :
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- virology : Coronavirus Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Demography, Female, Global Health, Humans, Infant, Male, Middle Aged, Risk Factors, Survival Rate.
Abstract
Although Middle East respiratory syndrome coronavirus (MERS-CoV) has a recorded 5 years of circulation in 27 countries worldwide, there is no international study to assess whether there is variation in mortality by region. Neither has there been a comprehensive study detailing how the disease characteristics of MERS-CoV influence mortality in patients presenting symptoms. This study aimed to assess how region, patient and disease characteristics influence 14- and 45-day mortality in MERS patients. The author utilised publically available data on MERS-CoV. The study included 883 MERS patients reported between 5 January 2015 and 10 March 2017. Data on patient and disease characteristics were collected. The mean age at MERS-CoV diagnosis was 54.3 years: 69.1% were male, and 86.7% of the cases were reported from Saudi Arabia. About 40% of MERS patients studied were over the age of 60. The study estimated 14- and 45-day survival rates after initial onset of symptoms: 83.67% and 65.9%, respectively. Saudi Arabian MERS patients exhibited 4.1 and 5.0 times higher 14-day (adjusted hazard risk (aHR) = 4.1; 95% confidence interval (CI) 1.012–16.921) and 45-day (aHR = 5.0; 95% CI 1.856–13.581) mortality risk compared with MERS patients in the Republic of Korea or other countries. Similarly, Middle Eastern MERS patients showed 5.3 and 4.1 times higher 14-day (aHR = 5.3; 95% CI 1.070–25.902) and 45-day (aHR = 4.1; 95% CI 1.288–113.076) mortality risk compared with MERS patients in the Republic of Korea or other countries. The results demonstrated a link between mortality and geography, disease and patient factors such as regions, symptoms, source of infections, underlying medical conditions, modes of transmission, non-healthcare workers and those of older age. Educational programmes, access to healthcare and early diagnosis could be implemented as modifiable factors to reduce the higher mortality rates in MERS patients.
Url:
DOI: 10.1017/S095026881700293X
PubMed: 29271336
PubMed Central: 7113020
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C52
- to stream Pmc, to step Curation: 000C52
- to stream Pmc, to step Checkpoint: 000863
- to stream PubMed, to step Corpus: 000A39
- to stream PubMed, to step Curation: 000A39
- to stream PubMed, to step Checkpoint: 000929
- to stream Ncbi, to step Merge: 001C94
- to stream Ncbi, to step Curation: 001C94
- to stream Ncbi, to step Checkpoint: 001C94
- to stream Main, to step Merge: 000E01
- to stream Main, to step Curation: 000D98
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29271336</idno><idno type="pmc">7113020</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113020</idno><idno type="RBID">PMC:7113020</idno><idno type="doi">10.1017/S095026881700293X</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C52</idno><idno type="wicri:Area/Pmc/Curation">000C52</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C52</idno><idno type="wicri:Area/Pmc/Checkpoint">000863</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000863</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:29271336</idno><idno type="wicri:Area/PubMed/Corpus">000A39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A39</idno><idno type="wicri:Area/PubMed/Curation">000A39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A39</idno><idno type="wicri:Area/PubMed/Checkpoint">000929</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000929</idno><idno type="wicri:Area/Ncbi/Merge">001C94</idno><idno type="wicri:Area/Ncbi/Curation">001C94</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C94</idno><idno type="wicri:doubleKey">0950-2688:2017:Ahmed A:estimating:survival:rates</idno><idno type="wicri:Area/Main/Merge">000E01</idno><idno type="wicri:Area/Main/Curation">000D98</idno><idno type="wicri:Area/Main/Exploration">000D98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Demography</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Démographie</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (virologie)</term><term>Mâle</term><term>Nourrisson</term><term>Santé mondiale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Demography</term><term>Female</term><term>Global Health</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Démographie</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Santé mondiale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although Middle East respiratory syndrome coronavirus (MERS-CoV) has a recorded 5 years of circulation in 27 countries worldwide, there is no international study to assess whether there is variation in mortality by region. Neither has there been a comprehensive study detailing how the disease characteristics of MERS-CoV influence mortality in patients presenting symptoms. This study aimed to assess how region, patient and disease characteristics influence 14- and 45-day mortality in MERS patients. The author utilised publically available data on MERS-CoV. The study included 883 MERS patients reported between 5 January 2015 and 10 March 2017. Data on patient and disease characteristics were collected. The mean age at MERS-CoV diagnosis was 54.3 years: 69.1% were male, and 86.7% of the cases were reported from Saudi Arabia. About 40% of MERS patients studied were over the age of 60. The study estimated 14- and 45-day survival rates after initial onset of symptoms: 83.67% and 65.9%, respectively. Saudi Arabian MERS patients exhibited 4.1 and 5.0 times higher 14-day (adjusted hazard risk (aHR) = 4.1; 95% confidence interval (CI) 1.012–16.921) and 45-day (aHR = 5.0; 95% CI 1.856–13.581) mortality risk compared with MERS patients in the Republic of Korea or other countries. Similarly, Middle Eastern MERS patients showed 5.3 and 4.1 times higher 14-day (aHR = 5.3; 95% CI 1.070–25.902) and 45-day (aHR = 4.1; 95% CI 1.288–113.076) mortality risk compared with MERS patients in the Republic of Korea or other countries. The results demonstrated a link between mortality and geography, disease and patient factors such as regions, symptoms, source of infections, underlying medical conditions, modes of transmission, non-healthcare workers and those of older age. Educational programmes, access to healthcare and early diagnosis could be implemented as modifiable factors to reduce the higher mortality rates in MERS patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Feikin, Dr" uniqKey="Feikin D">DR Feikin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Ghamdi, M" uniqKey="Al Ghamdi M">M Al Ghamdi</name></author><author><name sortKey="Alghamdi, Km" uniqKey="Alghamdi K">KM Alghamdi</name></author><author><name sortKey="Ghandoora, Y" uniqKey="Ghandoora Y">Y Ghandoora</name></author><author><name sortKey="Alzahrani, A" uniqKey="Alzahrani A">A Alzahrani</name></author><author><name sortKey="Salah, F" uniqKey="Salah F">F Salah</name></author><author><name sortKey="Alsulami, A" uniqKey="Alsulami A">A Alsulami</name></author><author><name sortKey="Bawayan, Mf" uniqKey="Bawayan M">MF Bawayan</name></author><author><name sortKey="Vaidya, D" uniqKey="Vaidya D">D Vaidya</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author><author><name sortKey="Sood, G" uniqKey="Sood G">G Sood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, Ae" uniqKey="Ahmed A">AE Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd, Ha" uniqKey="Mohd H">HA Mohd</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Alfaraj, Sh" uniqKey="Alfaraj S">SH Alfaraj</name></author><author><name sortKey="Mcclish, D" uniqKey="Mcclish D">D McClish</name></author><author><name sortKey="Altuwaijri, T" uniqKey="Altuwaijri T">T Altuwaijri</name></author><author><name sortKey="Alanazi, Ms" uniqKey="Alanazi M">MS Alanazi</name></author><author><name sortKey="Aloqiel, Sa" uniqKey="Aloqiel S">SA Aloqiel</name></author><author><name sortKey="Alenzi, Am" uniqKey="Alenzi A">AM Alenzi</name></author><author><name sortKey="Bafaqeeh, F" uniqKey="Bafaqeeh F">F Bafaqeeh</name></author><author><name sortKey="Mohamed, Am" uniqKey="Mohamed A">AM Mohamed</name></author><author><name sortKey="Aldosari, K" uniqKey="Aldosari K">K Aldosari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K Mizumoto</name></author><author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M Saitoh</name></author><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name></author><author><name sortKey="Miyamatsu, Y" uniqKey="Miyamatsu Y">Y Miyamatsu</name></author><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nam, Hs" uniqKey="Nam H">HS Nam</name></author><author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author><author><name sortKey="Yeon, My" uniqKey="Yeon M">MY Yeon</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Tandi, Te" uniqKey="Tandi T">TE Tandi</name></author><author><name sortKey="Choi, Jw" uniqKey="Choi J">JW Choi</name></author><author><name sortKey="Moon, Jm" uniqKey="Moon J">JM Moon</name></author><author><name sortKey="Kim, Ms" uniqKey="Kim M">MS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almekhlafi, Ga" uniqKey="Almekhlafi G">GA Almekhlafi</name></author><author><name sortKey="Albarrak, Mm" uniqKey="Albarrak M">MM Albarrak</name></author><author><name sortKey="Mandourah, Y" uniqKey="Mandourah Y">Y Mandourah</name></author><author><name sortKey="Hassan, S" uniqKey="Hassan S">S Hassan</name></author><author><name sortKey="Alwan, A" uniqKey="Alwan A">A Alwan</name></author><author><name sortKey="Abudayah, A" uniqKey="Abudayah A">A Abudayah</name></author><author><name sortKey="Altayyar, S" uniqKey="Altayyar S">S Altayyar</name></author><author><name sortKey="Mustafa, M" uniqKey="Mustafa M">M Mustafa</name></author><author><name sortKey="Aldaghestani, T" uniqKey="Aldaghestani T">T Aldaghestani</name></author><author><name sortKey="Alghamedi, A" uniqKey="Alghamedi A">A Alghamedi</name></author><author><name sortKey="Talag, A" uniqKey="Talag A">A Talag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F Elzein</name></author><author><name sortKey="Matin, Ma" uniqKey="Matin M">MA Matin</name></author><author><name sortKey="Selim, Ma" uniqKey="Selim M">MA Selim</name></author><author><name sortKey="Al Mutairi, M" uniqKey="Al Mutairi M">M Al Mutairi</name></author><author><name sortKey="Al Nakhli, D" uniqKey="Al Nakhli D">D Al Nakhli</name></author><author><name sortKey="Al Aidaroos, Ay" uniqKey="Al Aidaroos A">AY Al Aidaroos</name></author><author><name sortKey="Al Sherbeeni, N" uniqKey="Al Sherbeeni N">N Al Sherbeeni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K Mizumoto</name></author><author><name sortKey="Endo, A" uniqKey="Endo A">A Endo</name></author><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name></author><author><name sortKey="Miyamatsu, Y" uniqKey="Miyamatsu Y">Y Miyamatsu</name></author><author><name sortKey="Saitoh, M" uniqKey="Saitoh M">M Saitoh</name></author><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majumder, Ms" uniqKey="Majumder M">MS Majumder</name></author><author><name sortKey="Kluberg, Sa" uniqKey="Kluberg S">SA Kluberg</name></author><author><name sortKey="Mekaru, Sr" uniqKey="Mekaru S">SR Mekaru</name></author><author><name sortKey="Brownstein, Js" uniqKey="Brownstein J">JS Brownstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banik, Gr" uniqKey="Banik G">GR Banik</name></author><author><name sortKey="Alqahtani, As" uniqKey="Alqahtani A">AS Alqahtani</name></author><author><name sortKey="Booy, R" uniqKey="Booy R">R Booy</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rivers, Cm" uniqKey="Rivers C">CM Rivers</name></author><author><name sortKey="Majumder, Ms" uniqKey="Majumder M">MS Majumder</name></author><author><name sortKey="Lofgren, Et" uniqKey="Lofgren E">ET Lofgren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Chughtai, Aa" uniqKey="Chughtai A">AA Chughtai</name></author><author><name sortKey="Dyda, A" uniqKey="Dyda A">A Dyda</name></author><author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, Ae" uniqKey="Ahmed A">AE Ahmed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H Flemban</name></author><author><name sortKey="Al Nassir, Wn" uniqKey="Al Nassir W">WN Al-Nassir</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pavli, A" uniqKey="Pavli A">A Pavli</name></author><author><name sortKey="Tsiodras, S" uniqKey="Tsiodras S">S Tsiodras</name></author><author><name sortKey="Maltezou, Hc" uniqKey="Maltezou H">HC Maltezou</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D98 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D98 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7113020
|texte= Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29271336" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |